This episode of the UEG Podcast takes place at the EPC meeting in the summer of 2025. Our host Egle Dieninyte sits down with Professor Marco Del Chiaro, Surgical Oncologist and global lead of the upcoming Guidelines on Pancreatic Cystic Neoplasms. Tune in as they discuss why a unified, evidence-based approach is essential in this complex field, the challenges of managing cystic pancreatic lesions with limited high-quality data, and the balance between clinical judgement and guideline recommendations. Professor Del Chiaro also reflects on the limitations of current evidence, the evolving role of biomarkers, and how collaboration across continents may finally help standardise diagnosis, surveillance, and treatment for these patients. Insightful, candid, and forward-looking — this episode offers a rare behind-the-scenes view into how global consensus in pancreatic disease is built.