Around half of patients with pancreatic cancer are diagnosed after the disease has already spread. Dr Pilar Acedo Nuñez from UCL joins Eglė Dieninytė to discuss screening and why we still rely on CA 19-9, what the new RAS inhibitors could mean for patients, whether molecular profiling should be routine, and what the first-in-human KRAS vaccine trial has shown in people at high risk of pancreatic cancer. Part 2 will look at treatment options.

Rome V was published ten years after Rome IV. Maura Corsetti, co-chair of the Rome V Bowel Disorders committee, joins Pradeep Mundre to discuss the relaxed IBS criteria, three new adult diagnoses, the split between research and clinical criteria, and why explaining a gut-brain diagnosis early spares patients repeat investigation.

Flares, surgery and the postpartum period. Mette Julsgaard and Pradeep Mundre on whether active disease or a JAK inhibitor is the bigger risk, starting upadacitinib at 28 weeks, acute severe colitis and when to operate, vaccinating infants exposed to biologics.

Mette Julsgaard and Pradeep Mundre on IBD before and during pregnancy: what active disease costs in fertility, what to check at the preconception visit, and a drug by drug run through of what to stop, continue and start, from 5-ASAs and thiopurines to biologics and JAK inhibitors, as well as the use of low-dose aspirin.

Operate on every high-risk early oesophageal cancer after endoscopic resection and more than 80% of those patients gain nothing. Roos Pouw, Ana-Maria Bucalau and Jessie Elliott on strict endoscopic follow-up, the shift from chemoradiation to perioperative FLOT, and what ENSURE showed about surveillance after oesophagectomy.

UEG Podcast is on summer holiday and re-releases published episodes that we think deserve another listen. Enjoy!

In this episode of the UEG Talks conversation between Maria Vehreschild and Pradeep Mundre, we delve into the complexities of the faecal microbiome and the role of faecal microbiota transplantation (FMT) in treating various diseases, particularly C. difficile infections and inflammatory bowel disease (IBD). The discussion covers the historical context of FMT, its mechanisms of action, current treatment guidelines, safety considerations, and the various delivery methods. The conversation also emphasises the need for further research and the importance of professional standards in FMT practices.

UEG Podcast is on summer holiday and re-releases published episodes that we think deserve another listen. Enjoy!

Functional gastrointestinal disorders, or disorder of gut-brain interaction, can be frightening to many GIs. How do I talk to the patient? What can I tell them if there is no improvement in their symptoms? How can I even explain to them what their diagnosis is, if I don’t even know it?
To clear things up and provide clear points of action, our host Egle Dieninyte talked to Tim Vanuytsel from the University Hospital in Leuven, Belgium.

UEG Podcast is on summer holiday and re-releases published episodes that we think deserve another listen. Enjoy!

In this episode, host Egle speaks with former UEG President Axel Dignass about what it takes to lead in times of crisis. Drawing on his experience during the COVID-19 pandemic, Axel reflects on the difference between being a boss and being a true leader. He shares thoughts on the value of empathy, transparency, and consistency, as well as how to build and sustain a resilient team. The conversation also touches on the challenges of going virtual, the importance of recognising team achievements, and the warning signs of toxic leadership. A must-listen for anyone looking to grow as a leader in uncertain times.

Michael Bretthauer on the real epidemiology of colorectal cancer in the under-50s: a genuine rise from a tiny baseline, the carcinoid confounder inflating the numbers, lifestyle versus genetics, why screening ages shouldn't drop yet, and the ECOPOP trials testing endoscopic resection against surgery.

The 2024 MASLD treatment guidelines are already changing. Pradeep Mundre and Professor Sven Francque (Antwerp), guideline co-author, cover weight-loss targets (7% and 10%), resmetirom in F2-F3 fibrosis, semaglutide's positive phase 3 in MASH, plus pioglitazone, bariatric surgery, and liver transplantation in this population.