Part 2 will be released on Wednesday, the 29th of April.

Eosinophilic oesophagitis (EoE) is now a well-recognised condition. But it was not always so. In this episode, Prof. Alex Straumann shares how EoE was first identified, taking us back to the late 1980s when unusual cases of food impaction and eosinophilic inflammation did not fit any known diagnosis.

He discusses the clinical observations that led to recognising EoE as a distinct disease, the early case series that defined its phenotype, and the initial treatment approaches that shaped current practice. The episode also addresses key diagnostic challenges that remain relevant today, including the distinction from oesophageal eosinophilia and the limitations of symptom-based assessment.

In this episode, Pradeep Mundre speaks with Hannah Gordon about one of the most challenging areas in inflammatory bowel disease management: balancing effective treatment with cancer risk. As therapeutic options expand, clinicians increasingly face complex scenarios involving patients with prior malignancy in remission or those undergoing active cancer treatment. The discussion examines how cancer risk relates both to IBD itself and to immunosuppressive or biologic therapies. The episode highlights limitations in current evidence, differences across drug classes, and the importance of individualised decision-making. Emphasis is placed on multidisciplinary collaboration, patient communication, and navigating uncertainty in real-world clinical practice.

Cristian Costas, a leading dietitian in coeliac disease, shares insights on managing celiac disease through diet, setting up specialised services, and navigating dietary challenges. We explore diagnosis, implementation of a gluten-free diet, and strategies to improve patient outcomes.

In the second part of this in-depth conversation, host Egle Dieninyte continues her discussion with Professor Nageshwar Reddy, shifting the focus from technological innovation to ethics, responsibility and the human dimension of endoscopy.

Professor Reddy shares how mobile endoscopy units have brought life-saving care to rural populations, and why cascade hygiene strategies are sometimes necessary when resources are limited.

The conversation then turns to a topic rarely discussed openly: mistakes. What constitutes a true medical mistake? How do we distinguish adverse events from preventable errors? And why should ERCP only ever be performed with strict indication?

Finally, Professor Reddy reflects on mentorship, generational change, work–home balance, and why compassion is not an innate trait — but a skill that can and must be cultivated.

A powerful conclusion to a two-part conversation on what it really means to practise endoscopy.

What has truly transformed endoscopy over the past decades?

In this first part of a two-part conversation, host Egle Dieninyte sits down with Professor Nageshwar Reddy, one of the most influential pioneers in modern therapeutic endoscopy, to reflect on how the field has evolved — and where it is heading next.

From the transition from rigid to fibreoptic endoscopy, to the introduction of video systems that reshaped team dynamics in the endoscopy suite, Professor Reddy explains why some of the most powerful innovations were not necessarily the most glamorous ones.

The discussion also explores:
• Disposable scopes and environmental responsibility
• Antibiotic resistance and global practice differences
• The role of passion and compassion in medicine
• Regenerative endoscopy and stem cell applications
• The story behind the “Nagi stent”

Beyond technology, this episode offers a personal perspective on success, mentorship, and what it truly means to be a good endoscopist.

🎧 Listen now to Part 1 — and stay tuned for Part 2, which will be released in a week from now on the 4th of March.

- What happens when optical diagnosis and histology don’t align?
- Does better polyp detection always mean better outcomes?
- And how should AI, quality metrics and surveillance intervals really shape daily endoscopy practice?

In this special episode, we share an unfiltered round-table discussion recorded during the UEG Online Course on the impact of polyp detection in colonoscopy. Leading experts Raf Bisschops, Manuele Furnari, Veronique Van der Voort and Pieter Sinonquel debate real-world dilemmas around serrated lesions, pathology discordance, documentation, bowel preparation and the clinical consequences of rising ADRs.

Also watch it as a video podcast on Spotify

Listen now and explore the full course for free (login required) on gutflix.eu: [The impact of polyp detection in colonoscopy](https://gutflix.eu/r/i6GfsYAhus8u)

In this episode of the UEG Podcast, host Pradeep Mundre is joined by David Sanders, Professor of Gastroenterology at Sheffield and one of the world’s leading experts in coeliac disease.
Timed with the recent update of the British Society of Gastroenterology coeliac guidelines, the discussion explores why coeliac disease remains frequently underdiagnosed, even in specialist care. Together, they unpack the latest evidence on serology-based diagnosis, optimal biopsy strategies, potential and seronegative coeliac disease, and when HLA testing is truly useful.
The episode also covers long-term follow-up, the role of repeat biopsies, ultra-short coeliac disease, and emerging non-dietary therapies — including the realistic prospects of a future “pizza pill”.

Check out the newest guidelines on coeliac disease here:https://doi.org/10.1002/ueg2.70119

Immunotherapy might be revolutionising the way we fight GI cancers. In our latest episode, we dive into how this innovative treatment is changing patient outcomes and the role it plays in cancer management. To discuss this, we talked to Jeroen Dekervel, gastroenterologist and oncologist at the UZ Leuven in Belgium. Our host, Pradeep Mundre guides us through the conversation about how tumours develop a resistance to chemotherapy, the quality of life for oncological patients, and why the term "palliative treatment" for cancer patients could use an update.

In this thought-provoking episode of the UEG Podcast, host Egle Dieninyte sits down with organisational psychologist Lina Sopiene to explore one of medicine’s most unspoken challenges — burnout.
Together, they unpack why high-achieving healthcare professionals often equate self-worth with performance, how this mindset fuels exhaustion, and what practical steps can help doctors and nurses reconnect with themselves. From learning to “be a human being, not just a human doing” to managing workplace anger and setting healthy boundaries, this conversation is a candid look at the emotional realities of hospital life.
Lina offers grounded, compassionate insights on self-care, emotional regulation, and the art of saying no — lessons that every healthcare worker can relate to.
Honest, empathetic, and deeply relevant — a must-listen for anyone navigating the pressures of modern medicine.

This episode of the UEG Podcast takes place at the EPC meeting in the summer of 2025. Our host Egle Dieninyte sits down with Professor Marco Del Chiaro, Surgical Oncologist and global lead of the upcoming Guidelines on Pancreatic Cystic Neoplasms.
Tune in as they discuss why a unified, evidence-based approach is essential in this complex field, the challenges of managing cystic pancreatic lesions with limited high-quality data, and the balance between clinical judgement and guideline recommendations.
Professor Del Chiaro also reflects on the limitations of current evidence, the evolving role of biomarkers, and how collaboration across continents may finally help standardise diagnosis, surveillance, and treatment for these patients.
Insightful, candid, and forward-looking — this episode offers a rare behind-the-scenes view into how global consensus in pancreatic disease is built.