Ten years after Rome IV, the Rome Foundation published Rome V in 2026, and with it a substantial revision of how disorders of gut–brain interaction (DGBI) are defined, diagnosed and managed. Pradeep Mundre is joined by Maura Corsetti, Associate Professor of Gastroenterology at the University of Nottingham, co-chair of the Rome V Bowel Disorders Committee and a member of the Rome Foundation Board of Directors, to work through what has actually changed, and what survives contact with a busy clinic..

Further reading

• Rome Foundation Brain–Gut Axis pocket card — the card Corsetti uses to explain the diagnosis; free download after registration.

• Disorders of Gut–Brain Interaction and the Rome V Process — Drossman, Chang & Tack, Gastroenterology 2026;170:1083–98. The Rome V overview: nomenclature, the split between research and clinical criteria, and the rationale for each new diagnosis.

• Bowel Disorders — Corsetti, Shin, Lacy et al., Gastroenterology 2026;170:1261–82. Corsetti's own Rome V chapter, containing the revised IBS criteria discussed at length.

• Centrally Mediated Disorders of Gastrointestinal Pain — Fukudo, Aziz, Drossman et al., Gastroenterology 2026;170:1283–302. Where adult abdominal migraine (D2) and narcotic bowel syndrome sit in Rome V.

• Anorectal Disorders — Rao, Bharucha, Carrington et al., Gastroenterology 2026;170:1318–46. The new anorectal sensory dysfunction disorders and their assessment and treatment.

• Rome Foundation Clinical Diagnostic Criteria for Disorders of Gut-Brain Interaction — Gastroenterology 2022;162:675–9. The precursor to the Rome V clinical criteria, developed with primary care input.

• The prevalence and impact of overlapping Rome IV-diagnosed functional gastrointestinal disorders — Aziz, Palsson, Törnblom et al., Am J Gastroenterol 2018;113:86–96. The three-country population study underlying the overlap and quality-of-life data.

• Rome V: a global framework for disorders of gut–brain interaction — Rome Foundation. Where to find the Rome V products and criteria.